Leishmaniasis Parasites Evade Death By Exploiting The Immune Response To Sand Fly Bites
Cutaneous leishmaniasis, a disease characterized by painful skin ulcers, occurs when the parasite Leishmania major, or a related species, is transmitted to a mammalian host by the bite of an infected sand fly. In a new study from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, scientists have discovered L.
‘Flu Vaccination’ Protects Bacteria Against Virus
Bacteria like people animals and plants can become infected by a virus. Researchers at Wageningen University, together with colleagues from England and the United States, have unravelled a mechanism with which bacteria can defend themselves for a longer period against threatening viruses. Over the long term, this research offers possibilities to protect bacteria used in industrial processes against viral infections by giving them a ‘flu vaccination’.
Scientists To Develop Rheumatoid Arthritis Vaccine
Scientists in the UK are hoping to develop a new vaccine using patients’ own blood cells to suppress the effects of rheumatoid arthritis; if successful the work will signal a major breakthrough in the treatment of the auto-immune disease. Newcastle University’s Musculoskeletal Research Group is to carry out the research, which is being funded by a 216,000 pound grant from the medical research charity the Arthritis Research Campaign.
DNA Vaccine Delivery Technology Shows Promise In Inducing Stronger Immune Responses
Inovio Biomedical Corporation (AMEX:INO), a leader in enabling the development of DNA vaccines using a proprietary electroporation-based DNA delivery platform, announced today it has expanded its research license with the International AIDS Vaccine Initiative (IAVI), a leading organization dedicated to ensuring the development of safe and effective preventive HIV vaccines.
Protein Complementarity May Offer New Insights Into Autoimmune Diseases
The discovery of “complementary” antibodies against plasminogen in patients with blood vessel inflammation caused by anti-neutrophil cytoplasmic autoantibodies (ANCAs) may lead to new approaches to research, testing, and treatment of ANCA vasculitis and other autoimmune diseases, suggests a paper in the December Journal of the American Society of Nephrology (JASN).
How Flesh Eating Bacteria Attack The Body’s Immune System
“Flesh-eating” or “Strep” bacteria are able to survive and spread in the body by degrading a key immune defense molecule, according to researchers at the University of California, San Diego, School of Medicine and Skaggs School of Pharmacy and Pharmaceutical Sciences. The finding, which could aid in development of new treatments for serious infections in human patients, will be reported in the August 14 issue of the journal Cell Host & Microbe.
Isis Initiates Clinical Trial Of CRP Drug
Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced it has initiated a Phase 1 study of ISIS 353512, an antisense drug that inhibits the production of C-reactive protein (CRP). CRP levels are frequently elevated in patients with a variety of diseases including cardiovascular disease, Crohn’s disease, rheumatoid arthritis and end-stage renal disease.
Nasal Hepatitis B Vaccine Elicits Robust Immunity With A Single Dose; Confers Major Advantages Over Traditional Vaccines
A new study has shown that a nasal hepatitis B vaccine elicits a dramatic immune response in animals without requiring three vaccinations, sterile syringes or refrigeration-three factors that impede the delivery of current hepatitis B vaccines. In the study, a single dose of the nasal vaccine triggered a protective response in animals roughly 450 times greater than that elicited by currently approved human vaccines.